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"Mechanosensitivity in Cells and Tissues as an Overall Regulatory System Kamkin and Kiseleva's assembly of leaders in the mechanosensitivity eld provides an excellent broad based and up-to-date book, with chapters in the rst part d- cussing mechanically gated channels (mechanogated), mechanosensitive channels (MGC,MSC) systems(asthe editorsair thenomenclatureintheireditorial),thes- ond describing their signaling, and the third presenting aspects of cell mechanobi- ogy. Conceptually starting with tension at the surface membrane, the book's theme movesonto somemolecularmechanisms,andthenonto MSC as initiatingcomplex cell signal cascades, sometimes invoking signalsomes. Mechanosensitivity is also described in organs. Mechanosensitivitydoes not only relate to very soft deformabletissue, but ch- ters also focuses on cells and tissues concerned essentially with skeletal growth and development. The state of the art covered in the book heralds, to me, a slant to mechanosensitivity in general. Galileo remarked in 1638 that longer bones were thicker for a given structural strength (Galilei, 1638) (translation in (Crewew & da Silavio, 1939)), and this was followed in 1859 by Darwin's noting that ying ducks have underdevelopedlegs as compared with terrestrial bound ones (Darwin, 1859)."
"(Publisher-supplied data) This book presents the latest findings in mechanosensitive ion channel research compiled by a number of internationally recognized experts in the field of mechanosensitivity, specializing in mechanosensitive or mechanically gated ion channels and the underlying mechanosensitive signaling cascades. "Mechanosensitivity in Cells and Tissues: Mechanosensitive Ion Channels" defines and discusses key problems of cellular mechanobiology, describing the methods for studying mechanosensitive ion channels, the role of lipid bilayer mechanics in mechanosensation, and the molecular organization, physiology and pharmacology of the various ion channels, which react to changes in cellular membrane tension. The book provides a comprehensive description of mechanotransduction, which is defined as the biochemical response of cells to mechanical stimulation, and provides the reader with the latest vision of signaling cascades. These signaling cascades play an important role in modulation of function of mechanosensitive ion channels, as well as their reaction to changes in activity of mechanosensitive ion channels, located upstream of these cascades. This volume includes chapters describing different ways and effects of mechanical stimulation in various tissues and cells, which will be of particular interest for students and specialists, interested in the field of mechanosensitivity research. In summary, descriptions of the most widely used experimental models, the methods of choice and references to experimental protocols, the latest experimental findings and current vision, and potential problems in data interpretation, will be of considerable use to all those interested in this field of research."
""This book presents the latest findings in mechanosensitive ion channel research compiled by a number of internationally recognized experts in the field of mechanosensitivity, specializing in mechanosensitive or mechanically gated ion channels and the underlying mechanosensitive signaling cascades. "Mechanosensitivity in Cells and Tissues: Mechanosensitive Ion Channels" defines and discusses key problems of cellular mechanobiology, describing the methods for studying mechanosensitive ion channels, the role of lipid bilayer mechanics in mechanosensation, and the molecular organization, physiology and pharmacology of the various ion channels, which react to changes in cellular membrane tension. The book provides a comprehensive description of mechanotransduction, which is defined as the biochemical response of cells to mechanical stimulation, and provides the reader with the latest vision of signaling cascades. These signaling cascades play an important role in modulation of function of mechanosensitive ion channels, as well as their reaction to changes in activity of mechanosensitive ion channels, located upstream of these cascades. This volume includes chapters describing different ways and effects of mechanical stimulation in various tissues and cells, which will be of particular interest for students and specialists, interested in the field of mechanosensitivity research. In summary, descriptions of the most widely used experimental models, the methods of choice and references to experimental protocols, the latest experimental findings and current vision, and potential problems in data interpretation, will be of considerable use to all those interested in this field of research."--Publisher's description."@en
"This book presents the latest findings in mechanosensitive ion channel research compiled by a number of internationally recognized experts in the field of mechanosensitivity, specializing in mechanosensitive or mechanically gated ion channels and the underlying mechanosensitive signaling cascades. "Mechanosensitivity in Cells and Tissues: Mechanosensitive Ion Channels" defines and discusses key problems of cellular mechanobiology, describing the methods for studying mechanosensitive ion channels, the role of lipid bilayer mechanics in mechanosensation, and the molecular organization."@en

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