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Receptor signal transduction protocols

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  • "A collection of state-of-the-art methods for interrogating ligand-receptor and receptor-effector interactions. Methods emphasize the regulation of G protein-coupled receptors and focus on receptor characterization, methods for investigating how receptors couple to G proteins, and approaches to studying how receptor expression and function is regulated. The easily reproducible protocols include chimeric receptor construction, antibody generation, transient and stable transfection methods, hybridization, as well as immunocytochemistry, functional assays of G protein function, and antisense methods for defining receptor-effector coupling pathways."
  • "[Publisher-supplied data] As our understanding of G protein-coupled receptor (GPCR) signal transduction continues to grow, we cannot help but be struck by the emerging complexity and the ability of this receptor superfamily to continually surprise us as new facets are discovered. In this third edition of Receptor Signal Transduction Protocols, the expert contributors have taken into account the constant evolution of the GPCR field and dealt with methods that allow researchers to address many of the important rising issues. Serving as a companion to the previous editions, this volume contains thorough revisions of some core chapters, the complete rewriting of others to encompass new technological developments since the publication of the prior editions, and the commissioning of brand new, cutting-edge chapters to expand on previous coverage. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to the respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Receptor Signal Transduction Protocols, Third Edition serves the scientific community with a broad collection of the current, practical methodologies in this highly promising field."
  • "This new edition combines updates of key chapters from the first edition with a large number of new key methodologies that have emerged more recently for studying G protein-coupled receptors (GPCRs) and events immediately downstream of their activation. The methods are focused primarily on events at the receptor level, including ligand binding, the genetic manipulation of receptors, the generation of model cell lines in which to study them, and the interaction and activation of G-proteins. Additional methods concentrate on receptor expression and localization, receptor internalization and post-translational modification, GPCR-protein interactions, and the use of knock-out and knock-in strategies for determining the physiological roles of receptors."

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  • "Laboratory Manuals"@en
  • "Laboratory Manuals"
  • "Internet Resource"@en
  • "Aufsatzsammlung"
  • "Elektronisches Buch"
  • "Electronic books"
  • "Electronic books"@en
  • "Handbooks and manuals"
  • "Fulltext"@en
  • "Llibres electrònics"

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  • "Receptor signal transduction protocols"@en
  • "Receptor signal transduction protocols"
  • "Receptor Signal Transduction Protocols"@en
  • "Receptor Signal Transduction Protocols"

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