http://worldcat.org/entity/work/id/1057079210

New treatment strategies for dengue and other flaviviral diseases

Dengue fever is becoming more prevalent and is regarded as an 8216;emerging disease8217;. After an initial infection with the virus, which is transmitted by mosquitoes, lifelong immunity develops to the viral serotype that caused the infection. However, there are four dengue serotypes and subsequent infection with a different one can lead to dengue haemorrhagic fever/dengue shock syndrome, which can be fatal. There is no currently available effective treatment or vaccine. This book brings together an international group of experts on dengue and related flaviviruses to examine, critically, current knowledge regarding the dengue virus, the host response and the pathogenesis of dengue haemorrhagic fever and to explore the opportunities to develop new treatments. Issues addressed include the molecular biology of the dengue virus with particular emphasis on its structure and function and on the targeting of virus proteins by potential anti-viral agents. The interaction of the dengue virus with host target cells and the specific receptors on these cells is reviewed. Finally, the book outlines the options for treatment of dengue and dengue haemorrhagic fever, paying particular attention to ways in which vector, host and environment can play a critical role in the spread of this disease. A unique feature of this series is the in-depth discussion sections at the end of each chapter: these record the questions, comments and opinions of the experts in the field concerning all areas of research into dengue viruses and potential treatments.

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