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Molecular neurosurgery with targeted toxins

Gives a treatment of the highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. This book explains the theory and techniques of using targeted toxins experimentally.

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  • "Gives a treatment of the highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. This book explains the theory and techniques of using targeted toxins experimentally."@en
  • "The use of targeted cytotoxins to make highly selective neural lesions for both experimental and clinical purposes has already provided important animal models for diseases such as Alzheimer's, and holds great promise for research and clinical application to pain. In Molecular Neurosurgery With Targeted Toxins, pioneers in the field describe their hands-on experience with the experimental use of these toxins. The authors focus on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins."
  • "This book uses molecular neurosurgery techniques to model Alzheimer's disease in animals; adapts numerous vivid examples of real life applications to new research areas; helps the reader to understand the theoretical basis of molecular neurosurgery using targeted cytotoxins; and also helps the reader to learn about new cytotoxic agents being developed to treat chronic intractable pain."

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  • "Electronic books"@en
  • "Online-Publikation"
  • "Methods (Music)"
  • "Ressources Internet"

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  • "Molecular Neurosurgery With Targeted Toxins"
  • "Molecular neurosurgery with targeted toxins"@en
  • "Molecular neurosurgery with targeted toxins"
  • "Molecular Neurosurgery with Targeted Toxins"@en
  • "Molecular Neurosurgery with Targeted Toxins"

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