Lectins [WorldCat Entities]

"Since publication of the first edition in 1989, great strides have been made in several areas of lectin research. Numerous lectins have been isolated from a variety of sources, and their functions in infection, inflammation and immunity, both innate and acquired, have been clarified. In addition, the three-dimensional structures of close to 200 lectins, and of many of their complexes with carbohydrates have been elucidated, providing an insight into the molecular basis of their specificity. As a result, this book is about 470 pages long (three times the size of the first edition), with over 200 figures and some 30 tables. The book starts with an overview of lectin research followed by a survey of the occurrence of lectins in nature and a detailed description of their properties, with emphasis on specificity, structure and interaction with ligands at the atomic level. The biosynthesis and genetics of lectins are then discussed, as are their numerous applications in biology and medicine. A summary of the nutritional effects of lectins follows, and finally their functions in nature are dealt with."@en
"Lectins: Analytical Technologies covers both analytical and biological aspects of lectins (functional carbohydrate (complex sugar) recognition proteins) and provides researchers in the field with a resource containing background information and 'look-up' tables detailing lectin specificity and structures. Also included are methods and practical tips for designing new lectins from existing non-lectin proteins, automated approaches to lectin proteomics and high resolution mass spectrometry techniques. P This book will be of interest to both novice and advanced researchers in biomedical, analytical and pharmaceutical fields who are involved in the study of lectin structures or who utilize lectins as analytical tools. The study of lectins and their employment in analytical settings spans a range of fields including: * Crystallography and lectin structure databases * Carbohydrate microarrays for lectin characterization and glycotope identification * Proteomic approaches to the functional identification of bacterial adhesins * Generation of lectins from enzymes * Probing cell-surface lectins with neoglycoconjugates * Reviews up-to-date techniques, including practical hints for laboratory work * Provides overview of lectin e-resources and several color illustrations * Includes a 'look-up' table detailing lectin specificity."
"This is the second edition of our little red book Lectins published in 1989. In the intervening years well over 10,000 articles have appeared with lectins as the main subject, and more than twice as many in which they were touched upon, as well as around 20 books. In particular, great strides have been made in several areas of lectin research, about which little was known until the late 1980s. One prominent example is animal lectins, many of which have been discovered only during the last decade and the functions of several of which have been clarified, especially as to their key role in innate immunity. Another is the structure of lectins and of their combining sites. Thus, whereas at that time the three-dimensional structures of just three lectins and a few of their complexes with sugars had been elucidated, their numbers have increased to about 160 and over 200, respectively, and continue to grow unabated. Updating the information on these and other topics resulted in a marked expansion of the book, which is now nearly four times as long as the first edition, with 226 figures and 39 tables. Still, a few topics, such as carbohydrate-binding cytokines or bacterial toxins that are sometimes considered as lectins, have been dealt with only in passing. Similarly to the first edition, Lectins II starts with an overview of the history of lectin research."
"Lectins: Analytical Technologies covers both analytical and biological aspects of lectins (functional carbohydrate (complex sugar) recognition proteins) and provides researchers in the field with a resource containing background information and 'look-up' tables detailing lectin specificity and structures. Also included are methods and practical tips for designing new lectins from existing non-lectin proteins, automated approaches to lectin proteomics and high resolution mass spectrometry techniques. This book will be of interest to both novice and advanced researchers in biomedical, analytical and pharmaceutical fields who are involved in the study of lectin structures or who utilize lectins as analytical tools. The study of lectins and their employment in analytical settings spans a range of fields including: * Crystallography and lectin structure databases * Carbohydrate microarrays for lectin characterization and glycotope identification * Proteomic approaches to the functional identification of bacterial adhesins * Generation of lectins from enzymes * Probing cell-surface lectins with neoglycoconjugates * Reviews up-to-date techniques, including practical hints for laboratory work * Provides overview of lectin e-resources and several color illustrations * Includes a 'look-up' table detailing lectin specificity."@en
"Lectins: Analytical Technologies covers both analytical and biological aspects of lectins (functional carbohydrate (complex sugar) recognition proteins) and provides researchers in the field with a resource containing background information and 'look-up' tables detailing lectin specificity and structures. Also included are methods and practical tips for designing new lectins from existing non-lectin proteins, automated approaches to lectin proteomics and high resolution mass spectrometry techniques. This book will be of interest to both novice and advanced researchers in biomedical, analytical and pharmaceutical fields who are involved in the study of lectin structures or who utilize lectins as analytical tools. The study of lectins and their employment in analytical settings spans a range of fields including: * Crystallography and lectin structure databases * Carbohydrate microarrays for lectin characterization and glycotope identification * Proteomic approaches to the functional identification of bacterial adhesins * Generation of lectins from enzymes * Probing cell-surface lectins with neoglycoconjugates * Reviews up-to-date techniques, including practical hints for laboratory work * Provides overview of lectin e-resources and several color illustrations * Includes a 'look-up' table detailing lectin specificity."
"This monograph, aimed at graduate students and researchers in biology and related areas, deals with lectins, an exceedingly important class of diverse and widely occurring proteins that bind carbohydrates. They possess the unique ability to decode the information encoded in carbohydrates and thus to act as recognition determinants in diverse biological processes, both normal and pathological. Their study is therefore inextricably linked to glycobiology, a subject now in a stage of explosive growth. Since the publication of the first edition of this book in 1989, great strides have been made in several areas of lectin research. Numerous lectins have been isolated from a variety of sources, and their functions in infection, in inflammation and in immunity, both innate and acquired, have been clarified. In addition, the three-dimensional structures of close to 200 lectins, and of many of their complexes with carbohydrates has been elucidated, providing an insight into the molecu."
"A handbook of classic and emerging techniques to study lectins and protein-carbohydrate-interactions."@en