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Stem cells and cancer stem cells therapeutic applications in disease and injury

Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods.

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  • "Therapeutic applications in disease and injury"
  • "Therapeutic applications in disease and injury"@en

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  • "Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods."
  • "Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods."@en
  • "This volume provides an overview of stem cells and cancer stem cells. Topics include the application of human pluripotent stem cells, mesenchymal stem cells, hematopoietic stem cells in cancer therapy, tissue/organ regeneration, and more."@en
  • "The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells, and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on the."@en
  • "The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained."
  • "This fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. Showcasing the work of more than 80 contributors from 13 nations, it offers an unrivalled breadth of differing perspectives on the subject, with dedicated sections covering umbilical cord, induced pluripotent, embryonic, and hematopoietic stem cells, in addition to stem cells in tumors and cancer, and the applications of stem cells in regenerative medicine. ℗¡ Enhanced by numerous color illustrations and tables that provide graphic clarification and summaries of key results, the volume succeeds in bringing together research results from oncologists, neurosurgeons, physicians, research scientists, and pathologists, whose accumulated wealth of practical experience will inform and inspire further developments in the vital and urgent work of cancer diagnosis, cure, and prevention."
  • "They cover a formidable array of topics and offer differing scientific perspectives on specific, and in some cases highly controversial, aspects of cancer treatment and tissue regeneration. The section on stem cell culture includes information on developing defined culture conditions for expanding mesenchymal stromal cells in preparation for clinical applications. The importance of optimization of culture conditions and conservation of natural three-dimensional cell shape and morphology is pointed out because they are critical factors in maintaining cell phenotype and controlling differentiation. Regarding bone marrow stem cells, researchers share data on the gene expression profiling of myelodysplastic stem cells; the section on reprogramming and differentiation features the latest research focusing on epigenetic modifiers.-"
  • "It is difficult to overstate the potential applications of stem-cell biology to our understanding of, and responses to, disease and injury. This volume aims to bring to its readers authoritative and responsive coverage of aspects of the field that will keep them up-to-date in a fast-moving scientific landscape. The fourth volume in the series on stem cells and their cancer-carrying counterparts, this book sets out the plethora of therapeutic applications offered by a group of specific stem cells in tackling disease and tissue injury. The list of subjects includes embryonic, induced pluripotent, human hair follicle, bone marrow-derived human mesenchymal, adipose-derived, cancer, and breast cancer stem cells, in addition to periodontal/progenitor cells. The adaptability of human embryonic stem cells, which have the potential to develop into any cell type, ensures them an especially detailed treatment. Contributions explore the causal influence of cancer stem cells in malignancies such as cancer and breast cancer, and delineate the way mesenchymal stem cells contribute to the growth and metastasis of colon cancer. Shifting from disease to treatment, the text explains the therapeutic value of transplanting mesenchymal stem cells to the injured brain as an aid to its recovery. It includes material, too, on the exciting prospect of valuable new targeted cancer drugs borne of our increasing understanding of the molecular pathways peculiar to tumor biology. Key topics, such as the benefit of stem cell transplantation to immune system recovery among severe combined immunodeficiency patients, and the treatment of malignant gliomas using genetically modified neural stem cells as markers, provide a window on cutting-edge work in these specialized subjects. The extensive scope and detailed analysis of this volume, and of the series to which it belongs, mean that whether readers want a breakdown of the impact being made by cancer stem cell research on the design of next-generation cancer therapies, or details of the way stem cells could transform regenerative medicine by repairing damage to vital organs and tissues, they will find these-and much more-here."@en
  • "It is difficult to overstate the potential applications of stem-cell biology to our understanding of, and responses to, disease and injury. This volume aims to bring to its readers authoritative and responsive coverage of aspects of the field that will keep them up-to-date in a fast-moving scientific landscape. The fourth volume in the series on stem cells and their cancer-carrying counterparts, this book sets out the plethora of therapeutic applications offered by a group of specific stem cells in tackling disease and tissue injury. The list of subjects includes embryonic, induced pluripotent, human hair follicle, bone marrow-derived human mesenchymal, adipose-derived, cancer, and breast cancer stem cells, in addition to periodontal/progenitor cells. The adaptability of human embryonic stem cells, which have the potential to develop into any cell type, ensures them an especially detailed treatment. Contributions explore the causal influence of cancer stem cells in malignancies such as cancer and breast cancer, and delineate the way mesenchymal stem cells contribute to the growth and metastasis of colon cancer. Shifting from disease to treatment, the text explains the therapeutic value of transplanting mesenchymal stem cells to the injured brain as an aid to its recovery. It includes material, too, on the exciting prospect of valuable new targeted cancer drugs borne of our increasing understanding of the molecular pathways peculiar to tumor biology. Key topics, such as the benefit of stem cell transplantation to immune system recovery among severe combined immunodeficiency patients, and the treatment of malignant gliomas using genetically modified neural stem cells as markers, provide a window on cutting-edge work in these specialized subjects. The extensive scope and detailed analysis of this volume, and of the series to which it belongs, mean that whether readers want a breakdown of the impact being made by cancer stem cell research on the design of next-generation cancer therapies, or details of the way stem cells could transform regenerative medicine by repairing damage to vital organs and tissues, they will find these-and much more-here."
  • "It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, human mesenchymal stem cells, cancer stem cells, arterial stem cells, neural stem cells, cardiac stem cells, de."@en
  • "It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, human mesenchymal stem cells, cancer stem cells, arterial stem cells, neural stem cells, cardiac stem cells, dental stem cells, limbal stem cells, and hematopoietic stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. These cells are used in tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. It is pointed out that the formation of embryoid bodies, which are three-dimensional aggregates of embryonic cells, is the initial step in the differentiation of these cells. Therapeutic implications of signalling pathways in cancer stem cells are pointed out. Targeting self-renewal pathways in cancer stem cells are also included. Application of mesenchymal stem cells for treating ischemic brain injury is explained. Neural stem cells proliferation into the surrounding area of the traumatic brain injury is explained."
  • "As in volume 1 of this series, this volume presents information on stem cells and cancer stem cells; Therapeutic Applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this volume. Specific stem cells discussed are: human embryonic stem cells, hematopoietic stem cells, cord blood stem cells, human pluripotent stem cells, gliosarcoma stem cells, induced pluripotent stem cells, intestinal stem cells, human thyroid cancer stem cells, tumor stem cells, menstrual stem-like cells, neural stem cells, breast cancer stem cells, allogeneic mesenchymal stem cells, fetal membrane-derived mesemchynmal stem cells, and omental stem cells. The method for isolating bone marrow stromal cells is explained. Method for generating marmoset-induced pluripotent stem cells, using transcription factors, is also explained. Use of stem cell lines in therapeutic applications is discussed. Programming of stem cells is described. Methods for transplantation of stem cells are presented. Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier's disease, and neurogenerative diseases in general, is explained. For example, generation of human cardiac muscle cells from adipose-derived stem cells is included. Another example is repairing bone defects using mesenchymal stem cells and mesenchymal-derived endothelial cells. Differentiation of new neurons from neural stem cells is described. Method for repairing retina condition using human embryonic stem cells is explained; these cells can induce neural differentiation. Treatment of graft-versus-host disease resulting from hematopoietic stem cell transplantation is elaborated."@en

editor

genre

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  • "Livres électroniques"
  • "Electronic books"@en
  • "Electronic books"
  • "Aufsatzsammlung"
  • "Online-Publikation"

name

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  • "Stem cells and cancer stem cells therapeutic applications in disease and injury"@en
  • "Stem Cells and Cancer Stem Cells, Volume 9 Therapeutic Applications in Disease and Injury"
  • "Stem cells and cancer stem cells therapeutic applications in disease and injury"
  • "Stem Cells and Cancer Stem Cells, vol. 5 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 6"
  • "Stem cells and cancer stem cells : therapeutic applications in disease and injury. Volume 4"@en
  • "Stem Cells and Cancer Stem Cells Vol. 2: Therapeutic Applications in Disease and Injury"@en
  • "Stem Cells and Cancer Stem Cells, vol. 6 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 8 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, vol. 1 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 5 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 5 Therapeutic Applications in Disease and Injury"@en
  • "Stem Cells and Cancer Stem Cells, vol. 9 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, vol. 2 Therapeutic Applications in Disease and Injury"
  • "Stem cells and cancer stem cells : therapeutic applications in disease and injury / Vol. 4"
  • "Stem cells and cancer stem cells stem cells and cancer stem cells, therapeutic applications in disease and injury"
  • "Stem cells and cancer stem cells : therapeutic applications in disease and injury"
  • "Stem cells and cancer stem cells : therapeutic applications in disease and injury"@en
  • "Stem Cells and Cancer Stem Cells, Volume 4 : Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells"@en
  • "Stem Cells and Cancer Stem Cells Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury"@en
  • "Stem Cells and Cancer Stem Cells Vol. 5, Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 6 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 6 Therapeutic Applications in Disease and Injury"@en
  • "Stem sells and cancer stem cells. Volume 4 therapeutic applications in disease and injury"@en
  • "Stem sells and cancer stem cells. Volume 4 therapeutic applications in disease and injury"
  • "Stem cells and cancer stem cells : therapeutic applications in disease and injury / Volume 11"
  • "Stem Cells and Cancer Stem Cells, vol. 4 Therapeutic Applications in Disease and Injury"
  • "Stem cells and cancer stem cells. Volume 11 : therapeutic applications in disease and injury"@en
  • "Stem cells and cancer stem cells. Therapeutic applications in disease and injury"
  • "Stem cells and cancer stem cells. Therapeutic applications in disease and injury"@en
  • "Stem cells and cancer stem cells therapeutic applications in disease and injury / Volume 4"
  • "Stem Cells and Cancer Stem Cells, Volume 5"
  • "Stem Cells and Cancer Stem Cells, Volume 10 Therapeutic Applications in Disease and Injury"
  • "Stem cells and cancer stem cells. 4"
  • "Stem Cells and Cancer Stem Cells, Volume 4 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 4 Therapeutic Applications in Disease and Injury"@en
  • "Stem Cells and Cancer Stem Cells, vol. 8 Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 11 Therapeutic Applications in Disease and injury"
  • "Stem Cells and Cancer Stem Cells, Volume 5 : Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells, Volume 6 : Therapeutic Applications in Disease and Injury"
  • "Stem Cells and Cancer Stem Cells Vol. 1: Therapeutic Applications in Disease and Injury"@en

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