"Pharmazeutische Chemie." . . "Pharmazeutische Chemie" . "Structure-Activity Relationship." . . "MEDICAL Pharmacy." . . "Chemistry Techniques, Synthetic." . . "MEDICAL Drug Guides." . . . "Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologi."@en . . "Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section." . . . . "Livres électroniques" . . . . . . . . . "Llibres electrònics" . . . . . . . "Bioisosteres in Medicinal Chemistry" . . "Aufsatzsammlung" . . . . . . . . "Bioisosteres in medicinal chemistry"@en . "Bioisosteres in medicinal chemistry" . . . . "Bioisosteres In Medicinal Chemistry" . . . . . . . . . . "Electronic books" . "Electronic books"@en . . . . . "MEDICAL Pharmacology." . . "Wiley InterScience." . . "Pharmaceutical chemistry." . . "Pharmaceutical chemistry" . "Chimie pharmaceutique." . . "Physicochemical Phenomena." . . "MEDICAL Nursing Pharmacology." . . "Bioisosterie." . . "Bioisosterie" . "Chemistry, Pharmaceutical." . . "Química farmacèutica." . . . . "Médicaments Conception." . . "Molecular Structure." . .