http://worldcat.org/entity/work/id/137018113

The responses of animals inhaling nitrogen dioxide for single, short-term exposures

These experiments were designed to study the effects of NO2 at various concentration levels below the LC50 (Lethal Concentration 50) for single, short-exposure periods to obtain concentrations causing minimal effects to animals. Rats and rabbits were exposed to various concentrations of NO2 for 5 to 60 minutes and the LC50's calculated. In addition, rats and dogs were exposed for single 5 to 60 minute periods to various concentrations of NO2 below the rat LC50's. Toxic signs, pathologic changes in the lung and lung-to-body weight ratios correlated directly with the severity of exposure to NO2. Dogs showed only mild toxic signs at concentrations causing pulmonary edema in rats. Based on lung-to-body weight ratios and pathologic changes found, the concentrations of NO2 at which minimal effects found were 104, 65, and 28 ppm for 5, 15, and 60 minutes, respectively.

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