WorldCat Linked Data Explorer

Turtle N-Triple JSON-LD RDF/XML HTML Contact Us Home

http://worldcat.org/entity/work/id/312638056

Terminal Transferase in Immunobiology and Leukemia

Open All Close All

type

about

http://schema.org/about

contributor

creator

description

http://schema.org/description

  • "This book contains the proceedings of a conference devoted to the study of the structure and function of Terminal deoxynucleotidyl Transferase (TdT) and its utilization as biochemical marker in immunobiology and leukemia, held in Elba, Italy on May 28-31, 1981. The enzyme has been known to nucleic acid biochemists for more than 20 years and has proved to be an excellent tool for making deoxypolymers, labeling DNA fragments, and adding homopolymer tails to restriction endonuclease fragments from DNA. Since the discovery of its peculiar tissue distribution, normally restricted to the thymus and bone marrow, and of its abnormal occurrence in human leukemic lymphoblasts, TdT has become one of the most widely used markers in the study of lymphocyte differentiation and in the classification of hematopoietic neoplasia. The subject seemed most appropriate for a meeting where molecular and cellular biologists, immunologists and hematologists could convene for the first time to discuss both basic research and the clinical aspects of the problem. Among the goals achieved by this workshop was the sharing of information about the enzymology of TdT, biochemical and immunological methodology and the correlation of TdT with other markers in the diagnosis of leukemia. The remarkable accordance of results, presented here by five independent hematological institutions, from analysis of TdT in several thousands of leukemic patients, marks the importance of this enzyme as a diagnostic and prognostic tool in these diseases. The discussion about the ontogeny of lymphocytes was of particular interest, since terminal transferase represents a very specific intracellular marker for prelymphocytes and appears to be associated with the development of cells in B and T lineage. The conference was attended by 45 researchers from Australia, Austria, France, Germany, Israel, Italy, Japan, Switzerland, United Kingdom and USA. The enthusiastic participation of all the attendants, the high quality of their presentations, the uninterrupted discussion and the friendly atmosphere all contributed towards the success of the meeting. We believe that the application of terminal transferase in the diagnosis of leukemia is an outstanding contribution from basic science to clinical medicine and stems from fruitful cooperation between distant disciplines. This book reflects that experience. It also provides a reference for information scattered in many different journals and gives an up-to-date account of the new and exciting developments in the terminal transferase story."

editor

genre

http://schema.org/genre

  • "DNS-nucleotidyltransferase"
  • "Aufsatzsammlung"
  • "Electronic books"@en
  • "Conference papers and proceedings"

name

http://schema.org/name

  • "Terminal transferase in immunobiology and leukemia : proc. of an EMBO workshop, held May 28-31, 1981, in Elba, Italy"
  • "Terminal transferase in immunobiology and leukemia : Proceedings of an EMBO workshop on terminal transferase in immunobiology and leukemia, held May 28-31, 1981. in Elba, Itlay"
  • "Terminal Transferase in Immunobiology and Leukemia"@en
  • "Terminal transferase in immunobiology and leukemia"
  • "Terminal transferase in immunobiology and leukemia : [proceedings of an EMBO Workshop on Terminal Transferase in Immunobiology and Leukemia, held May 28-31,1981,in Elba, Italy]"

workExample