http://worldcat.org/entity/work/id/323372169

Effect of forward acceleration on renal hemodynamics, electrolyte excretion, and water clearance

The effect of forward acceleration on renal hydrodynamics, electrolyte excretion, and water clearance has been studied in six normal human subjects. Forward acceleration produced a slight increase in glomerular filtration rate and effective renal plasma flow during and after stress. Following centrifugation there was a 20-35 minute lag before the appearence of an increase in urine volume and free water clearance. These changes in water excretion were transient, not accompanied by a natruresis nor associated with changes in serum osmolality. Physiologic responses to forward acceleration and negative pressure breathing were compared. We concluded forward acceleration, like negative pressure breathing, induces an increase in intrathoracic blood volume which inhibits the release of antidiuretic hormone via a nonosmotic, volume sensitive receptor mechanism located within the intrathoracic vascular space.

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