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Mechanisms of Stimulus--Response Coupling in Platelets

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  • "Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attributable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behavior of platelets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechanisms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area cell receptor/ligand interaction, induction of cellular response by protein phosphorylation and calcium flux. The mechanism of these latter events occurs through the activity of phospholipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eicosanoids, reinforce and make irreversible the cellular response. Other developments related to platelet function have been in understanding of the functionalities of platelets in their interactions with other cellular and vascular elements, and components of the coagulation system. Because of the rapid developments which were occurring the symposium MECHANIAMS OF STIMULUS RESPONSE COUPLING IN PLATELETS was organized and took place at the Institute of Psychiatry, University of London, on 26th and 27th September 1984, and was attended by 300 participants. The format of this book is the same as that of the symposium and was designed to examine in sequence each of the steps in platelet functionality from primary interaction between ligand and receptor through to the functional interaction with other physiological elements."

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  • "Conference proceedings"@en
  • "Reizbeantwortung"
  • "Electronic books"
  • "Conference papers and proceedings"
  • "Conference papers and proceedings"@en
  • "Kongress"

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  • "Mechanisms of stimulus response coupling in platelets : Proceedings of an (european) symposium, Sept. 27-28, 1984, London"
  • "Mechanisms of stimulus-response coupling in platelets : Proceedings of a symposium held September 27-28, 1984 in De Crespigny Park, London"
  • "Mechanisms of Stimulus-Response Coupling in Platelets"
  • "Mechanisms of stimulus-response coupling in platelets : [proceed. of a symposium ... held Sept. 27-28, 1984, in De Crespigny ParkLondon, England]"
  • "Mechanisms of stimulus response coupling in platelets : [proceedings of a symposium entitled "Mechanisms of Stimulus - Response Coupling in Platelets", held Sept. 27-28, 1984 in De Crespigny Park, London, England]"
  • "Mechanisms of Stimulus--Response Coupling in Platelets"@en
  • "Mechanisms of stimulus-response coupling in platelets : [proceedings of a Symposium Entitled Mechanisms of Stimulus-Response Coupling in Platelets, held September 27-28, 1984, in London]"
  • "Mechanisms of stimulus-response coupling in platelets : [proceedings of a symposium ... held September 27-28, 1984, in De Crespigny Park, London, England]"
  • "Mechanisms of stimulus-response coupling in platelets"
  • "Mechanisms of stimulus-response coupling in platelets"@en

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