"A liberacao dos hormonios gastro entero pancreaticos foi investigada em dez portadores de Doenca de Chagas cronica e os resultados obtidos comparados e analisados estatisticamente com os observados em nove controles. A avaliacao hormonal baseou-se na determinacao serica das concentracoes da gastrina, glucagon pancreatico, polipeptidio pancreatico, enteroglucagon, motilina e colecistocinina, em condicoes basais e pelos, estimulos direto (administracao venosa de secretina e de ceruleina) e misto (administracao venosa de secretina eintra-duodenal de fenilalanina). A liberacao dos hormonios gastro-entero-pancreaticos, em condicoes basais e pelo estimulo direto, encontra-se preservada nos chagasicos a excecao da gastrina, que se apresenta significativamente mais elevada, tanto em condicoes basais como pelo estimulo pela secretina. A liberacao do polipeptideo pancreatico mostrou-se significativamente reduzida nos chagasicos cronicos pelo estimulo com a fenilalanina. As alteracoes detectadas na resposta hormonal sugerem comprometimento neural do eixo entero-pancreatico nesses pacientes (AU)."@pt
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