"Se determina la actividad de acetilcolinoesterasa (AchE) en 2 cerebros de pacientes que cumplen los criterios de demencia por infartos multiples. Se demuestra una disminucion de la actividad de AchE en el cortex prefrontal, parietal, hipocampo y nucleo basal de Meynert, la que afecta de manera particular a las fibras, con conservacion de la actividad en los somas neuronales. Se postula que la inhibicion de los sistemas colinergicos del telencefalo basal, tendrian algun rol en la genesis de la demencia por multiples infartos (AU)."@es
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