"Los disenos experimentales de pneumocystosis han permitido conocer en detalle a pneunocystis carinii, asi como mejorar su diagnostico, profilaxis y tratamiento. Se describe la induccion de pneumonia por este agente en ratas, mediante betametasona subcutanea bisemanal. Los grupos tratados incluyen las variables de betametasona sola, y betametasona con distintos grados de desnutricion. Las tinciones para diagnosticar P. carinii son el azul de toluidina y la metenamina argentica. En todas las ratas inmunosuprimidas se logro recuperar P. carinii y la mayor intensidad se alcanza entre la 10a. y 14a. semanas, especialmente desnutridas. A las ratas testigo no se comprobo pneumoniae por este agente. Con este diseno se controla adecuadamente las dosis de corticoides administradas y permite utilizar muestras de pulmon con P. carinii como control de las tecnicas de diagnostico de pneumocystosis (AU)."@es
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