"Se realizo un estudio clinico experimental controlado a doble ciego con el proposito de comparar el efecto antiinflamatorio, analgesico y alivio del trismus de Meloxicam 15mg. Y Piroxicam 20mg. usado pre y post quirurgico en pacientes sometidos a cirugia de terceros molares. Participaron en el estudio 20 pacientes, los cuales presentaban sus terceros molares incluidos o semiincluidos en igualdad de condiciones. Se programaron 2 intervenciones (derecha e izquierda) con intervalo de dos semanas entre ambas, se asigno al azar el farmaco antiinflamatorio. Todos los registros postoperatorios fueron consignados a las 48 horas. Se utilizo el metodo fotografico computacional para medir el edema facial, registrandose el aumento del contorno facial postquirurgico. Para medir el dolor se utilizo un metodo objetivo consistente en cuantificar el numero de analgesicos (Clonixinato de Lisina) consumidos por el paciente en el postoperatorio. El trismus fue determinado mediante la disminucion de la apertura bucal. Al comparar los efectos terapeuticos de ambos farmacos los resultados muestran una leve diferencia en el grado de disminucion del trismus a favor de Meloxicam, sin embargo, esta diferencia no tuvo significativa estadistica. En relacion a la reduccion del edema, Meloxicam presento una mejor actividad antiinflamatoria con una mediana evidencia estadistica. En la evaluacion del dolor, Meloxicam desarrollo una mayor actividad analgesica que Piroximan con diferencias estadisticamente significativas. De nuestros resultados concluimos que Meloxicam 15mg. tiene un mejor comportamiento terapeutico que Piroxicam 20mg. en el tratamiento de la inflamacion y el dolor postquirurgico en cirugia de terceros molares (AU)."@es
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Agentes antiinflamatorios no esteroides Uso terap.
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