"Los padecimientos alergicos estan geneticamente determinados y afectan del 20 al 30 por ciento de la poblacion general en paises desarrollados; en la ultima decada la prevalencia se ha incrementado. El desequilibrio manifiesto en los padecimientos atopicos se encuentra en las celulas presentadoras de antigeno (monocitos y celulas B) y en los linfocitos T CD4+. La asociacion de moleculas como CD80, CD 86 (moleculas co-estimulatorias) en monocitos y celulas B; y CD30, CD62L, ALL, CD11a, CD28, CD124 y CD152 en CD4+, ha demostrado ser de particular interes en padecimientos atopicos. Sin embargo, no se encontro una diferencia estadisticamente significativa entre pacientes y controles y entre reto nasal con solucion salina y alergeno. Por esto se sugiere que los cambios en la activacion, proliferacion y cooperacion se dan en el sitio de la lesion, sin una aparente repercusion en las celulas de la sangre periferica. (AU)."@es
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