Biosynthesis : polyketides and vitamins [WorldCat Entities]

"Aromatic polyketides, isoprenoids, alkaloids"@en

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"This book is concerned with discovering the chemical pathways of biosynthesis. The four chapters cover the use of isotopes in biosynthetic research and the biosynthesis of enzyme cofactors and vitamin B12 and of reduced polyketides such as erythromycin. The topics covered demonstrated the revolution that has occurred in biosynthetic studies with the advent of gene cloning and overexpression. The knowledge of biosynthetic pathways at the genetic and enzymic levels which is becoming available opens up possibilities of designing inhibitors of particular steps as new antibiotics or manipulating the genes so that new natural products are produced. However the book also shows that the more classical approach to biosynthetic studies must go hand in hand with these new techniques."@en
"This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). Volume 1 covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry."@en