Neurotransmitter transporters structure, function, and regulation [WorldCat Entities]

"A comprehensive survey of recent advances made in characterizing neurotransmitter transporters - including their imaging in the living brain - and in elucidating the processes underlying biological transport. The expert contributors present up-to-date findings on the molecular cloning of transporters and on neurotransmitter families both in plasma membranes and in storage vesicles. They also provide essential information on the structure activity relationships for a multitude of recently synthesized dopamine uptake blockers, on transporter changes in the context of human drug abuse, and on the role of transporters in the action of uptake blockers in vivo. The book opens the new frontier of transporters research, authoritatively presenting new insights into their roles in such diseases as brain ischemia and ALS, and into their involvement as targets for antidepressants, antiepileptics, drugs of abuse, and neurotoxins."
"A comprehensive survey of recent advances made in characterizing neurotransmitter transporters-including their imaging in the living brain-and in elucidating the processes underlying biological transport. The expert contributors present up-to-date findings on the molecular cloning of transporters and on neurotransmitter families both in plasma membranes and in storage vesicles. They also provide essential information on the structure-activity relationships for a multitude of recently synthesized dopamine uptake blockers, on transporter changes in the context of human drug abuse, and on the role of transporters in the action of uptake blockers in vivo. The book opens the new frontier of transporters research, authoritatively presenting new insights into their roles in such diseases as brain ischemia and ALS, and into their involvement as targets for antidepressants, antiepileptics, drugs of abuse, and neurotoxins."@en
"Integrating the many recent advances from DNA technology, Maarten Reith and his contributors fully update all the material in his highly acclaimed first edition, expanding it to include the important progress made in characterizing the structure, function, regulation, and physiological relevance of each transporter. The new material includes discussions of gene organization and the relationship of polymorphisms of monoamine transporters with a variety of diseases, transgenic animals carrying altered genes for plasma membrane monoamine transporters, and the regulation of transporters by trafficking in relation to their phosphorylation state. Also addressed are transporter imaging techniques that allow in vivo measurement in men and animals, chimera and site-directed mutagenesis studies, and transporter electrophysiology. Many chapters will be of interest to physicians carrying out imaging and postmortem measurements of neurotransmitter transporters in the human brain, and to physicians who study the relation of gene linkages and polymorphisms to psychiatric and other complex human diseases. Complete and up-to-date, Neurotransmitter Transporters: Structure, Function, and Regulation, Second Edition continues to be the most informative and useful review of this most active field, allowing comparison between the characteristics of various neurotransmitter transporters and their biological roles in such a way that progress for one transporter can help move work on another transporter forward."@en