"Pharmacokinetics." . . "Pharmacokinetics" . "pharmacokinetics" . "Leki metabolizm." . . "Drug Evaluation, Preclinical." . . "Drug Evaluation, Preclinical" . "Farmakokinetyka." . . "Design." . . "Relation structure-activité (Biochimie)" . . "Pharmaceutical chemistry. Drugs Structure-activity relationships. Drug development. Drugs Design. Drug Design. Drug Evaluation, Preclinical. Drug Toxicity. Pharmaceutical Preparations metabolism." . . "Drogas Relaciones estructura-actividad." . . "Projektowanie leków." . . "Struktur-Aktivitäts-Beziehung." . . "Médicaments Relations structure-activité" . . "Médicaments Relations structure-activité." . "Medicaments Desenvolupament." . . "Médicament." . . "Toksyczność leków." . . "Pharmaceutical Preparations." . . "pharmaceutical preparations" . "Structure-Activity Relationship." . . "Structure-Activity Relationship" . "structure-activity relationship" . "MyiLibrary (Service en ligne)" . . "Badanie leków przedkliniczne." . . "Pharmaceutical chemistry." . . "Pharmaceutical chemistry" . "Zależność czynnościowo-strukturalna." . . "Desenvolupament de medicaments." . . "Medicamentos Relação estrutura-atividade (Bioquímica)" . . "Médicaments Développement." . . "Medicaments Disseny." . . "Médicaments Mise au point." . . "Drugs Structure-activity relationships." . . "Drugs Structure-activity relationships" . "Structure-activity relationships." . . "industrie produit pharmaceutique [études diverses]" . . "preclinical drug evaluation" . . "MEDICAL Drug Guides." . . "Drug Toxicity." . . "Drug Toxicity" . "drug toxicity" . "Pharmazeutische Chemie." . . "Arzneimitteldesign." . . "Chimie pharmaceutique." . . "Drug development." . . "Drug development" . "Drugs Design." . . "Drugs Design" . . . "Farmacologie." . . "MEDICAL Pharmacy." . . "Química farmacèutica." . . "Química farmacéutica." . "Quimica farmaceutica." . "Disseny de medicaments." . . "Relacions estructura-activitat (Bioquímica)" . . "Pharmaceutical Preparations Metabolism." . . "Pharmaceutical Preparations metabolism." . "Pharmaceutical Preparations metabolism" . "Médicaments Conception." . . "Développement de médicaments." . . "Drogas Toxicologia." . . "Drug Design." . . "Drug Design" . "drug design" . "Drogas Diseño." . . "Drugs." . . "Medicaments." . . . . . . . "Drug-like properties concepts, structure design and methods : from ADME to toxicity optimization"@en . . "Drug-like properties concepts, structure design and methods : from ADME to toxicity optimization" . "Drug-like properties : concepts, structure design and methods: from ADME to toxicity optimization" . . "Drug-like Properties from ADME to Toxicity Optimization" . . . . . . . . . . . . . "Drug-like properties: concepts, structure design and methods from ADME to toxicity optimization" . . "Drug-like Properties Concepts, Structure Design and Methods from ADME to Toxicity Optimization"@en . . . . . . . . . . . . . "Drug-like properties : concepts, structure design and methods : from ADME to toxicity optimization"@en . "Drug-like properties : concepts, structure design and methods : from ADME to toxicity optimization" . . . . . . "Drug-like properties : concepts, structure design and methods ; from ADME to toxicity optimization" . . . . . . . . . . . . . . "Drug-like properties : concepts, structure design and methods from ADME to toxicity optimization" . . . . . . . . "Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint." . "Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint."@en . . . "Llibres electrònics" . . . . . . . "Drug-like properties : concepts, structure design and methods ; from ADME to toxicity optimization ; [metabolism, solubility, pharmacokinetics, permeability, CYP inhibition, toxicity, prodrugs]" . . . . . . . . . "Drug-like Properties: Concepts, Structure Design and Methods : from ADME to Toxicity Optimization" . . . "Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for." . . . . . "Livre électronique (Descripteur de forme)" . . . . . . . . . . . . . . . . "Drug-like properties" . "Elektronische boeken" . "Ressource Internet (Descripteur de forme)" . . . "Providing scientists and students with the knowledge to help you succeed."@en . . . . "Electronic books" . . "Electronic books"@en . . . . . . . . . . . . "Farmacocinètica." . . "Farmacocinetica." . "Drug-Related Side Effects and Adverse Reactions." . . "Medicaments Relacions d'estructura-activitat." . . "Pharmacocinétique." . . "Desarrollo de drogas." . . "Farmacologie. Therapie." . . "Toxicitat dels medicaments." . . "Pharmakokinetik." . . "MEDICAL Nursing Pharmacology." . . "Toxicité." . . "MEDICAL Pharmacology." . . "médicament recherche scientifique [études diverses]" . . "Metabolism." . . "metabolism" . "Conception." . . "Electronic books." . .