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Cellular Oscillatory Mechanisms

Offers an introduction to a range of both well known and less familiar cellular oscillations and illustrates the striking richness of cellular dynamics. This book focuses on elucidating the basic mechanisms that underlie these oscillations.

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  • "Offers an introduction to a range of both well known and less familiar cellular oscillations and illustrates the striking richness of cellular dynamics. This book focuses on elucidating the basic mechanisms that underlie these oscillations."@en
  • "Living systems are fundamentally dynamic and adaptive, relying on a constant throughput of energy. They are also, by definition, self-sustaining over the full range of length and time scales. This characteristic combination of constant adaptive flux and emergent persistence requires that the properties of all living systems must, at some level, be cyclical. Consequently, oscillatory dynamics, in which system properties rise and fall in a regular rhythmic fashion, are a central feature of a wide range of biological processes. The scale of biological oscillations covers enormous ranges, from the sub-cellular to the population level, and from milliseconds to years. The current resurgence in interest in interdisciplinary approaches to cell and molecular biology stems in part from the increasing availability of system-wide data on the state of the components of cellular regulatory networks. Alimiting factor in these approaches is often the lack of suitable ways of characterising a."
  • "Living systemsare fundamentally dynamic and adaptive, relying on a constant throughput of energy. They are also, by definition, self-sustaining over the full range oflength and time scales (from sub-cellular structures to species considered as a whole). This characteristic combinationofconstant adaptive flux and emergent persistence requires that the propertiesofall living systems must, at some level, be cyclical. Consequently, oscillatory dynamics, in which system properties rise and fall in a regular rhythmic fashion, are a central featureofa wide rangeofbiological processes. The scale of biological oscillations covers enormous ranges, from the sub-cellular to the population level, and from milliseconds to years. While the existenceofanumberofbiologicaloscillations-such as the regular beating of the human heart or the life-cycle ofa unicellular organism-is widely appreciated, therearemanyoscillatoryphenomenathataremuchlessobvious,albeit no less important. Since oscillations reflect periodic quantitative changes in system properties,theirdetectionandcharacterisationreliesonthequantitativemeasurement ofa systemoveranextendedperiod. Untilrecently, suchmeasurements were difficult toobtainatcellularorsub-cellularresolution, andrelatively few cellularoscillations had been described. However, recent methodological advances have revealed that oscillatory phenomena are as widespread in cells as they are at larger scales. The chapters inthis bookprovide an introduction to arangeofbothwellknown and less familiar cellular oscillations and serve to illustrate the striking richness of cellular dynamics. The contributions focus particularly on elucidating the basic mechanisms that underlie these oscillations. The essentially quantitative nature of oscillations has longmade theman attractive areaofstudyfor theoretical biologists (see, for example, refs. 1-3), and the application ofcomplementary modelling and experimental approachescanyieldinsightsintooscillatorydynamics thatgobeyond those that can be obtained by either in isolation. The benefits ofthis synergy are reflected in the contributions appearing in this book."
  • "The chapters in this book provide an introduction to a range of both well known and less familiar cellular oscillations and serve to illustrate the striking richness of cellular dynamics. The contributions focus particularly on elucidating the basic mechanisms that underlie these oscillations. The essentially quantitative nature of oscillations has long made them an attractive area of study for theoretical biologists, and the application of complementary modelling and experimental approaches can yield insights into oscillatory dynamics that go beyond those that can be obtained by either in isolation. The benefits of this synergy are reflected in the contributions appearing in this book. The current resurgence in interest in interdisciplinary approaches to cell and molecular biology stems in part from the increasing availability of system-wide data on the state of the components of cellular regulatory networks. Alimiting factor in these approaches is often the lack of suitable ways of characterising a network state in terms of summary quantitative features. Without such features, it is typically difficult to gain new qualitative insight into the operating logic of all but the simplest networks. In this regard, oscillatory phenomena provide ideal exemplars for systems approaches, since oscillations have clear summary features that prove invaluable in combining mathematical models with experimental data."@en

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  • "Electronic books"
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  • "Cellular Oscillatory Mechanisms"@en
  • "Cellular Oscillatory Mechanisms"
  • "Cellular oscillatory mechanisms"@en
  • "Cellular oscillatory mechanisms"