"Assaigs clínics de medicaments." . . . . . . . . . . . . "\"Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and skepticism. Surrogate endpoints are useful when they can be measured earlier, more conveniently, or more frequently than the \"\"true\"\" endpoints of primary interest. Regulatory agencies around the globe, particularly in the United States, Europe, and Japan, are introducing provisions and policies relating to the use of surrogate endpoints in registration studies. But how can one establish the adequacy of a surrogate? What kind of evidence is needed, and what statistical methods portray that evidence most appropriately? This book offers a balanced account on this controversial topic. The text presents major developments of the last couple of decades, together with a unified, meta-analytic framework within which surrogates can be evaluated from several angles. Methodological development is coupled with perspectives on various therapeutic areas. Academic views are juxtaposed with standpoints of scientists working in the biopharmaceutical industry as well as of colleagues from the regulatory authorities.\"" . . . . . . . . . . . . . . . "Online-Publikation" . . . . . . . . . . . . . . . . . "The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and scepticism. This book offers a balanced account on this controversial topic."@en . . . . . . . . . . . . . "The evaluation of surrogate endpoints" . "The evaluation of surrogate endpoints"@en . "The Evaluation of Surrogate Endpoints" . "The Evaluation of Surrogate Endpoints"@en . . . . . . . . . . "Llibres electrònics" . . "Electronic books"@en . "Electronic books" . . . "Drug Evaluation." . . "Leki badanie metody." . . "Statistik." . . "Biomathematica. Biometrie. Biostatistiek." . . "Clinical Trials as Topic." . . "Statystyka matematyczna stosowanie medycyna." . . "Statistics for Life Sciences, Medicine, Health Sciences" . . "Statistics." . . "Études cliniques." . . "SpringerLink (Service en ligne)" . . "Médicaments Essais cliniques." . . "Medizinische Statistik." . . "Klinische Prüfung." . . "medische statistiek." . . "Essais cliniques comme sujet." . . "Clinical Trials." . . "Clinical trials." . "Klinisches Experiment." . . "biostatistiek." . . "Biological Markers." . . "Estadística." . . "Arzneimittelprüfung." . . "MEDICAL Laboratory Medicine." . . "Essais cliniques des médicaments." . . "Wiskundige statistiek." . .