"Clinical Trials, Phase I as Topic methods." . . "Médicaments Relations dose-effet." . . "MEDICAL / Drug Guides / bisacsh." . . "MEDICAL Pharmacology." . . "Médicaments Développement." . . "Drug development." . . "MEDICAL Nursing Pharmacology." . . . . "MEDICAL Pharmacy." . . "MEDICAL / Pharmacology / bisacsh." . . "Models, Statistical." . . "MEDICAL Drug Guides." . . "Dose-Response Relationship, Drug." . . "Dose-Response Relationship, Drug" . "Drugs Dose-response relationship." . . . . . . . "As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to \"novel\" methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much attention in the medical community, though it has yet to become a commonplace tool. To overcome the status quo in phase I clinical trials, statisticians must be able to design trials using the CRM in a timely and reproducible manner. A self-contained theoretical framework of the CRM for researchers and graduate stu"@en . . . . . . . . . . . . . . . . . . "Dose Finding by the Continual Reassessment Method"@en . . . . . . . . . . . . . . . "Dose finding by the continual reassessment method" . "Dose finding by the continual reassessment method"@en . . . . . . . . . "Electronic books"@en . . . . "Wiskundige statistiek." . . "Clinical Trials, Phase I as Topic." . . "Clinical Trials, Phase I as Topic" . "MEDICAL / Pharmacy / bisacsh." . . "Biostatistics methods." . . "Biostatistics methods" . "Études cliniques." . . "Maximum Tolerated Dose." . . "Maximum Tolerated Dose" . "MEDICAL / Nursing / Pharmacology / bisacsh." . .