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Childhood leukemias

New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.

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  • "New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood."@en
  • "The most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases, from basic science to clinical management."@en
  • "Childhood leukemias represent nearly one third of all cancers in children and present a unique challenge to oncologists, pediatricians, hematologists, and other health professionals. The editor has assembled an expert team of authors to develop the most comprehensive, clinically-oriented, and authoritative reference dedicated to these diseases. The volume moves from the laboratory bench to the patient bedside in four easily-accessible sections: introductory chapters (including an interesting account of the historical development of treatment of leukemia and a clear review of the epidemiology and causes of leukemia in children), cell biology and pathobiology, evaluation and treatment, and complications and aspects of supportive care."
  • ""In the five years since publication of the second edition of Childhood Leukemias, new insights into the molecular and cellular biology of cancers in general, and of the leukemias in particular, have catalyzed exciting advances in diagnostic methods, strategies of risk assessment and the development of targeted and other novel forms of treatment. Encouraged by this progress, and the enthusiastic responses of readers of the previous edition, I willingly accepted the invitation to develop a third edition of this successful book. The rapid growth in our understanding of the biology of childhood leukemias and the accelerating pace of innovations in diagnostic and therapeutic approaches presented a considerable challenge during revision of the second edition. As you will notice, each chapter has been extensively modified or rewritten to accommodate the most recent information and references. Although structured to emphasize emerging themes in leukemia pathobiology and treatment, the reworked book still seeks to maintain a balance between fundamental pathophysiology and practical approaches to patient management, a standard that was central to the success of our earlier editions.Three chapters are entirely new. One deals with the epigenetics of leukemia, a topic that hasmoved rapidly to the fore of leukemia research.The discovery that aberrant epigenetic changes often cooperate with DNA sequence alterations in the initiation and progression of cancer, and that such changes are potentially reversible, has already led to clinical trials of therapies based on key epigenetic findings"--Provided by publisher."

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  • "Aufsatzsammlung"
  • "Electronic books"
  • "Electronic books"@en
  • "Odborné publikace"

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  • "Childhood leukemias"@en
  • "Childhood leukemias"
  • "Childhood Leukemias"@en
  • "Childhood Leukemias"

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