WorldCat Linked Data Explorer

Turtle N-Triple JSON-LD RDF/XML HTML Contact Us Home

http://worldcat.org/entity/work/id/1212046504

MHC class i antigens in malignant cells immune escape and response to immunotherapy

Open All Close All

type

about

http://schema.org/about

contributor

creator

description

http://schema.org/description

  • "Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develo"
  • "Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence℗¡that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches.℗¡A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. ℗¡Precise identification of the mechanism leading to MHC class I defects ℗¡will help to develop new personalized patient-tailored treatment protocols.℗¡There is significant new research℗¡on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is℗¡available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that℗¡show℗¡the℗¡progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on℗¡determining the final outcome of cancer immunotherapy.℗¡This SpringerBrief will present℗¡how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy. ℗¡"

genre

http://schema.org/genre

  • "Electronic books"
  • "Online-Publikation"

name

http://schema.org/name

  • "MHC class i antigens in malignant cells immune escape and response to immunotherapy"
  • "MHC class I antigens in malignant cells : immune escape and response to immunotherapy"
  • "MHC class I antigens in malignant cells immune escape and response to immunotherapy"
  • "MHC Class I Antigens In Malignant Cells Immune Escape And Response To Immunotherapy"

workExample