"En la epilepsia refractaria rebelde a monoterapia es beneficiosa la asociacion de farmacos como la fenotoina y la carbamazapina para evitar efectos toxicos por la monoterapia. Se administro fenitoina y carbamazapina por separado en dosis correspondientes a Dosis Efectiva (DE)50' DE40 y DE10 a un grupo de ratones. Luego se aplicaron combinaciones carbamazepina DE40 mas fenitoina DE 10' y carbamazepina DE9 mas fenitoina DE41 segun protocolo de Weaver, aplicando el test convulsivo de electrochoque maximo, en todos los casos. Se determinaron los niveles de GABA y glutamato en el hipocampo observandose que la carbamazepina disminuia signigicativamente los niveles de glutamato mientras que la fenitoina no (P<0.01). Ademas ambos farmacos aumentaron los niveles de GABA (P<0.01). Se determino que la combinacion de los farmacos, independientemente de su porcentaje de asociacion, aumentaba significativamente el porcentaje de proteccion con repecto al de cada farmaco por separado (P<0.01). De los resultados se concluye que la carbamazepina produce una disminucion estadisticamente significativa del nivel basal de glutamato y que la asociacion carbamazepina mas fenitoina produce un aumento estadisticamente significativo de la proteccion ante los tests convulsivos(AU)."@es
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