"When designing sustained release tablets for highly water-soluble active substances, a linear release profile during 16 hours for the active molecule is very hard to get. Among controlled release pharmaceutical forms, the hydrophilic matrix is commonly used. Nevertheless, when the active molecule is highly soluble in biological fluids, it becomes more difficult to slow down its release. The purpose of this study is to evaluate the interest of lipids associated with a hydrophilic polymer (hydrophilic-lipophilic matrix), to slow down the release of water-soluble active substances. During the study, sustained release tablets are prepared by wet granulation or hot melt granulation in order to evaluate the impact of the fabrication process on active substances release profile."
"Lors de la conception de comprimés à libération prolongée pour des principes actifs (PA) très hydrosolubles, une cinétique de libération de la molécule active linéaire sur 16 heures est difficile à obtenir. Parmi les formes pharmaceutiques visant à prolonger la libération d'un PA, la matrice hydrophile est très utilisée. Néanmoins, lorsque la molécule active est très soluble dans les fluides biologiques, ralentir sa libération sans avoir d'effet burst, devient plus difficile. L'objectif de cette étude est d'évaluer l'intérêt des matrices lipidiques en association avec un polymère hydrophile (matrice mixte) pour ralentir la libération de PA hydrosolubles. Au cours de l'étude, les comprimés à libération prolongée sont préparés par granulation humide ou par thermogranulation, afin d'évaluer l'impact du procédé de fabrication sur la cinétique de libération de molécules actives très solubles dans l'eau."
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Industrie pharmaceutique Thèses et écrits académiques.
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Médicaments Granulation Thèses et écrits académiques.
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Médicaments Solubilité Thèses et écrits académiques.
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